CURRICULUM VITAE

WAYNE JOHN G. HELLSTROM, M.D.

Tulane University Medical Center

Department of Urology

1430 Tulane Avenue, SL-42

New Orleans, LA 70112-2632

Telephone:504-587-7308 - Fax: 504-588-5059

E-mail: whellst@tmcpop.tmc.tulane.edu

DATE AND PLACE OF BIRTH: April 6, 1955, Detroit, Michigan

EDUCATION:

o B.SC. Physiology, McGill University, Montreal, P.Q. Canada, 1977

o M.D.C.M. McGill Medical School, Montreal, P.Q. Canada, 1981

o Internship: General Surgery, Montreal General and Royal Victoria Hospital, McGill University, Montreal, P.Q. Canada, 1981-1982

o Residency: General Surgery, Montreal General and Royal Victoria Hospital, McGill University, Montreal, P.Q. Canada, 1981-1983

o Urology, University of California, San Francisco, California, 1983-1985

o Chief Resident, Urology, University of California, San Francisco, 1985-1986

o Fellowship: Andrology, University of California, Davis, California, 1986-1988

CERTIFICATION:

Board of Medical Examiners, State of California #G49763, 1983

Drug Enforcement Administrative Reg. #AH3077193, 1983

Certification for Lithotripsy, AUA(UCSF), 1986

Certification for American Board of Urology, 1988; Recertification 1997

Louisiana State Board of Medical Examiners Cert. #07721R, 1988

Fellow of the American College of Surgeons, 1990

ESWL/Medstone Training Certificate, 1996

ACADEMIC POSITIONS HELD:

o Instructor, Department of Urology, University of California, Davis, California, 1986 - 1988

o Assistant Professor of Urology, Tulane University School of Medicine, New Orleans, Louisiana, 1988 - 1992

o Chief, Male Infertility and Sexual Dysfunction, Tulane University Medical Center, New Orleans, Louisiana, 1988 - Present

o Chief, Section of Urology, Charity Hospital of New Orleans, New Orleans, Louisiana, 1989 - Present

o Research Affiliate, Delta Regional Primate Research Center, Covington, Louisiana, 1989 - 1998

o Associate Professor of Urology, Tulane University School of Medicine, New Orleans, Louisiana, 1992 - 1999

o Professor of Urology, Tulane University School of Medicine, New Orleans, Louisiana, 1999 - present

HOSPITAL AFFILIATIONS:

Tulane University Hospital, New Orleans, Louisiana

Veterans Administration Medical Center, New Orleans, LA

Charity Hospital at New Orleans, New Orleans, Louisiana

Touro Infirmary, New Orleans, Louisiana

Doctors Hospital of Jefferson, Metairie, Louisiana

Huey P. Long Regional Medical Center, Pineville, LA

Lakeland Hospital, New Orleans, Louisiana

Pendleton Memorial Methodist Hospital, New Orleans, LA

Veterans Administration Medical Center, Alexandria, LA

Children’s Hospital, New Orleans, Louisiana

Columbia Lakeview Regional Medical Center, Covington, LA

Columbia Lakeside Medical Center, Metairie, LA

University Hospital, New Orleans, LA

PROFESSIONAL SOCIETIES:

American Fertility Society/American Society for Reproductive Medicine

American Medical Association (1988-1994)

American Society of Andrology

American Urological Association

Fellow of the American College of Surgeons

International Society for Impotence Research

Louisiana State Medical Society

Northern California Association of Urologists (1983-1988)

Orleans Parish Medical Society

Societe Internationale d'Urologie

Society of Genitourinary Reconstructive Surgeons (GURS)

Society of Male Reproduction and Urology

Society of University Urologists, Inc.

Southeastern Section of the AUA

Southern Medical Association

EDITORSHIPS:

1988 – Present Fertility and Sterility Journal (Reviewer)

1990 – Present Journal of Andrology (Reviewer)

1990 – Present Assisted Reproductive Technologies for Andrology. ARTA (Co-editor)

1991 – Present New England Journal of Medicine (Reviewer)

1992 – 1996 Journal of Andrology, Editorial Board Member

1993 – Present Journal of Urology (Reviewer)

1993 – Present Urology (Reviewer)

1995 – Present Journal of Clinical Investigation (Reviewer)

1995 – Present Biology of Reproduction (Reviewer)

1997 – Present Journal of Andrology, Associate Editor

1998 – Present Web Site Committee (Society for the Study of Sexual Dysfunction)

PUBLICATIONS IN REFERRED JOURNALS:

(Archived publications prior to 1995 available under separate cover)

Monga M; Moreno T; Hellstrom WJG: Gunshot wounds to the male genitalia: management for the clinical urologist. Contemporary Urology 7(1):58-63, 1995.

Monga M; Moreno T; Hellstrom WJG: Gunshot wounds to the male genitalia. J Trauma 38(6):855-8, 1995.

Monga M; Puyau FA; Hellstrom WJG: Posttraumatic high-flow internal pudendal artery-urethral fistula. J Urology 153(3 Pt 1):734-6, 1995.

Steele RH; Martin AA; Sikka SC; Hellstrom WJG: Penile intracavernosal substance abuse. Urology 45(4):686-88, 1995.

Rajasekaran M; Hellstrom WJG; Naz RK; Sikka SC: Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril. 64(1):166-71, 1995.

deBoisblanc MW; Robichaux WH; Hellstrom WJG: Large scrotal epidermal inclusion cyst and hydrocele. J La State Med Soc. 147(6):280-1, 1995.

Hellstrom WJG; Monga M; Sofikitis N: Current medical treatment of idiopathic oligozoospermia. Jpn J Fertil Steril. 40(3):386-97, 1995.

Sofikitis N; Miyagawa I; Dimitriadis D; Zavos P; Sikka SC; Hellstrom WJG: Effects of smoking on testicular function, semen quality, and sperm fertilizing capacity. J Urology 154(3):1030-34, 1995.

Lowentritt JE; Kawahara K; Human LG; Hellstrom WJG; Domingue GJ: Bacterial infection in prostatodynia. J Urology 154(4):1378-81, 1995.

Hellstrom WJG; Lewis R; Narayan P: Benign prostatic hyperplasia patient evaluation and treatment options. South Med J 5(3):7-8, 1996

Candella JV and Hellstrom WJG: Three-piece inflatable penis prosthesis implantation: a comparison of the penoscrotal and infrapubic surgical approaches. J La State Med Soc. 148(7):296-301, 1996.

Monga M and Hellstrom WJG: Medical Treatment for Male Infertility. Contemporary Urology 8(9):23-47, Sept. 1996.

Monga M; Broderick GA; Hellstrom WJG: Priapism in sickle cell disease: the case for early implantation of the penile prosthesis. Eur Urology 30(1):54-9, 1996.

Hellstrom WJG; Monga M; Cote D; Harmon E: Reconstruction of a total anterior urethral defect using buccal mucosa. South Med J. 89(11):1088-91, 1996.

Hellstrom WJG; Bennett AH; Gesundheit N; Kaiser FE; Lue TF; Padma-Nathan H; Peterson CA; Tam PY; Todd LK; Varady JC and Place VA: A double-blind, placebo-controlled evaluation of the erectile response to transurethral alprostadil. Urology 48(6):851-56, 1996.

PUBLICATIONS IN REFERRED JOURNALS (cont’d)

Rajasekaran M; Hellstrom W; Sikka S: Quantitative assessment of cytokines (GRO alpha and IL-10) in human seminal plasma during genitourinary inflammation. Am J Reprod Immunol. 36(2):90-5, 1996.

VandenBerg TL and Hellstrom WJG: Individualizing androgen replacement therapy. Contemporary Urology Supplement, p. 25-38, 1997.

Padma-Nathan H; Hellstrom WJG; Kaiser FE; Labasky RF; Lue TF; Nolten WE; Norwood PC; Peterson, CA; Shabsigh R; Tam PY; Place VA and Gesundheit N: Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated urethral system for erection (MUSE) study group. N Engl J Med. 336(1):1-7, 1997.

Ghoniem GM; Shoukry MS; Faced AAS; Hellstrom WJG and Sakr MA: Human vasal changes after vasectomy: In vitro studies. Eur Urology 31(2):231-36, 1997.

Champion HC; Wang R; Shenassa BB; Murphy WA; Coy DH; Hellstrom WJG; Kadowitz PJ: Adrenomedullin induces penile erection in the cat. Eur J Pharmacol. 319(1):71-5, 1997.

Wood JC; Monga M and Hellstrom WJG: Penile Calciphylaxis. Urology 50(4):622-4, 1997.

Labadie P and Hellstrom WJG: Hematospermia: Clinical directives. South Med J. 90(10):S127, 1997.

Champion HC; Wang R; Santiago JA; Murphy WA; Coy DH; Kadowitz PJ and Hellstrom WJG: Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model. J Andrology 18(5):513-21, 1997.

Champion HC; Wang R; Hellstrom WJ and Kadowitz PJ: Nociceptin, a novel endogenous ligand for the ORL1 receptor, has potent erectile activity in the cat. Am J Physiol. 273(1 Pt. 1):E214-19, 1997.

Estrada LS; Champion HC; Wang R; Rajasekaran M; Hellstrom WJ; Aggarwal B; and Sikka SC: Effect of tumor necrosis factor-alpha (TNF-") and interferon-( (IFN-() on human sperm motility, viability and motion parameters. Int J Androl 20(4):237-42, 1997.

Ahuja SK; Krane NK and Hellstrom WJ: Penile prostheses in the management of impotence in patients with end-stage renal disease. J La State Med Soc, 150(1):32-4, 1998.

Hellstrom WJG: Priapism: Approaches to management. AUA News, 3(1):14-15, 1998.

Hellstrom WJG; Wang R; Peterson C; Varady J; Gesundheit N and Sikka SC: Effects of alprostadil and prazosin on motility, viability and membrane integrity of human sperm. J Urology, 159(5):1559-62, 1998.

Peterson CA; Bennett AH; Hellstrom WJG; Kaiser FE; Morley JE; Nemo KJ; Padma-Nathan H; Place VA; Prendergast JJ; Tam PY; Tanagho EA; Todd LK; Varady JC and Gesundheit N: Erectile response to transurethral alprostadil, prazosin and alprostadia-prazosin combinations. J Urology, 159(5):1523-27; discussion 1527-8, 1998.

PUBLICATIONS IN REFERRED JOURNALS (cont’d)

Hellstrom WJG and Domingue GJ: Bacterial infection in prostatodynia (letter to editor: Dr. Peter M. Joseph). J Urology, 154:1378-1381 (1995), Editor’s Letter, 1998.

Netto Jr., RR; Esteves SC; Neves PA: Transurethral resection of partially obstructed ejaculatory ducts: Seminal parameters and pregnancy outcomes according to the etiology of obstruction. (Editorial Comment: Wayne J.G. Hellstrom) J Urology, 6(159):2048-53, 1998.

Armstrong JS; Rajasekaran M; Hellstrom WJG and Sikka SC: Antioxidant potential of human serum albumin: Role in the recovery of high quality human spermatozoa for assisted reproductive technology. J Andrology, 19(4):412-19, 1998.

Bivalacqua TJ; Champion HC; Kadowitz PJ, Doherty PC and Hellstrom WJG: Potentiation of erectile response by combination of prostaglandin E₁ and rolipram in the cat. Impotence Research, pp. 225-229, 1998.

Hellstrom WJG; Bivalacqua TJ; Kadowitz PJ and Doherty PC: Type 3, 4 and 5 phosphodiesterase inhibitors influence penile erection in the cat. Impotence Research, pp. 219-224, 1998.

Hellstrom WJG: When and how to treat the androgen-deficient male. Contemporary Urology, 10(9): 52-68, 1998.

Lasser A; VandenBerg TL; Vincent M and Hellstrom WJG: Intraplaque verapamil injection for treatment of Peyronie’s disease. J La Med Soc. 150(9):431-4, 1998.

Constabile RA; Spevak M; Fishman IJ; Govier FE; Hellstrom WJG; Shabsigh R; Nemo KJ; Rapport JL; Tam PY; Weldon KLM and Gesundheit N: Efficacy and safety of transurethral alprostadil in patients with erectile dysfunction following radical prostatectomy. J Urology 160(4):1325-8, 1998.

Bivalacqua TJ; Rajasekaran M; Champion HC; Wang R; Sikka SC; Kadowitz PJ and Hellstrom WJG: The influence of castration on pharmacologically induced penile erection in the cat. J Andrology, 19(5):551-7, 1998.

Domingue GJ and Hellstrom WJG: Prostatitis. Clin Microbiol Reviews, 11(4):604-13,Review. 1998.

Rajasekaran M; Mondal D, Agrawal K, Chen IL, Hellstrom WJG, and Sikka SC: Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells. J Urology, 160(6 Pt. 1):2210-15, 1998.

Champion HC; Bivalacqua TJ; Wang R; Hellstrom WJG; and Kadowitz PJ: [Tyr¹]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat. J Andrology, 19(6):747-753, 1998.

Armstrong JS; Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJ and Sikka SC: Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Bio Med 26(7/8):869-80, 1999.

Labadie P and Hellstrom WJG: Hematospermia: Diagnosis, evaluation, and clinical relevance. Contemporary Urology 11(4):125-9, 1999.

PUBLICATIONS IN REFERRED JOURNALS (cont’d)

Ahuja SK; Sikka SC and Hellstrom WJG: Stimulation of collagen production in an in vitro model of Peyronie’s disease. International Journal of Impotence Research 11;1-6, 1999.

Champion HC; Bivalacqua TJ; Wang R; Kadowitz PJ; Keefer LK; Saavedra JE; Hrabie JA; Doherty PC and Hellstrom WJG: Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat. J Urology 161:2013-19, 1999.

Ahuja SK; Bivalacqua TJ, Case J, Vincent MJ; Sikka SC and Hellstrom WJG: A pilot study demonstrating clinica benefit from intralesional Interferon Alpha 2b in the treatment of Peyronie’s disease. Journal of Andrology 20:444-448, 1999

Hellstrom WJG: Testosterone Replacement Therapy. In: Digital Urology Journal, website:

http://www.dug.com/Article/Hellstrom2/Hellstrom2.html. 1999

Shenassa B and Hellstrom WJG: Premature ejaculation: from historical origins to current treatment. Chronicle of Urology 7 Sexual Medicine Augst 1999, pp. 11-12

Champion HC, Bivalacqua TJ, Hyman AL, Ignarro LJ, Hellstrom WJG, and Kadowitz PJ: Gene-transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proceedings of the National Academy of Science Vol. 96:11648-11652 September 1999

Bivalacqua TJ; Champion HC; Rajasekaran M; Kadowitz PJ; Sikka SC; Doherty PC and Hellstrom WJG: Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). Journal of Urology (In Press), 1999

Hellstrom WJ: Testosterone Replacement Therapy. Digital Urology Journal (In press)

Bivalacqua TJ; Champion HC; Wang R; Kadowitz PJ; Doherty PC and Hellstrom WJG: Feline penile erection induced by transurethral administration of sodium nitroprusside. Urological Research (In press)

Bivalacqua TJ, Champion HC, Purohit SK, Murphy WA, Coy DH, Kadowitz PJ, and Hellstrom WJG: Nitric oxide-medicated erectile effects of galantide but not galanin in vivo. Nitric Oxide (Submitted), 1999

Hellstrom WJ: Application of Pericardial Graft in the Surgical Management of Peyronie’s Disease. (Submitted) Journal of Urology.

Overstreet JW; Fuh VL; Howards SS; Lieber MM; Hellstrom WJG, et al.: Chronic treatment with finasteride 1 mg/day does not affect spermatogenesis or semen production in young men. J Urology (Submitted), 1999

INVITED CHAPTERS AND REVIEWS:

Hellstrom WJG; McAninch JW; Lue TF: Priapism: Pathophysiology and treatment. In R.W. deVere White (Guest Ed.) Problems in Urology, Sexual Dysfunction. JB Lippincott Company, 1987.

Hellstrom WJG; Overstreet JW; Lewis EL: The clinical significance of antibodies in the treatment of male infertility. In R.W. deVere White (Guest Ed.) Problems in Urology, Sexual Dysfunction, JB Lippincott Company, 1987.

Hellstrom WJG: Immunologic Infertility and the Immunobead Test. In Common Problems In Infertility, Edited by J. Raifer and A. Wein, 1989.

Hellstrom WJG and Salvatore FT: Vacuum constriction devices: Are they useful? In World Book on Impotence Research: Basic and Clinical. Edited by Tom Lue. pp. 169-80, 1992.

Hellstrom WJG and Neal DE: The diagnosis and therapy of male genital tract infections. Infertility and Reproductive Medicine Clinics of North America, pp. 399-411, April 1992.

Sikka SC and Hellstrom WJG: The application of pentoxifylline in the stimulation of sperm motion in men undergoing electroejaculation. Treatment of Male Infertility in: Year Book of Infertility. Mosby Year Book Inc., p. 133, 1992.

Hellstrom WJG: The new injection treatment for impotence: Medical and psychological aspects, Wagner and Kaplan. (Review) N Engl J Medicine, 329(6):439-440, 1993.

Sikka SC and Hellstrom WJG: Vascular laboratory diagnosis of impotence. In: The Noninvasive Vascular Laboratory: Current Issues and Clinical Developments, editors: Auer and Neumyer, St. Louis, MO. (In press)

Wang R; Monga M; Hellstrom WJG: Ejaculatory Dysfunction. In: Textbook of Clinical Andrology, edited by Professor Frank Comhaire. (1995).

Monga M and Hellstrom WJG: Testicular Trauma In: Adolescent Medicine: State of the Art Reviews, 1996.

Monga M; Sofikitis N and Hellstrom WJG: Benign scrotal masses in the adolescent male: Varicoceles, spermatoceles, and hydroceles. Adolescent Medicine: State of the Art Reviews, 1996.

VandenBerg T and Hellstrom WJG: Hormonal evaluation and treatment of the patient with sexual dysfunction. In: The Diagnosis and Management of Male Sexual Dysfunction Edited by John J. Mulcahy, pgs. 35-54, 1996.

Hellstrom WJG: Surgical treatment of Peyronie's disease In: Textbook of Andrology: Relevant issues in male infertility and sexual dysfunction. Edited by Wayne J. G. Hellstrom. Allen Press, Inc. Chapter 36, 1997.

Monga M and Hellstrom WJG: Testicular Torsion and Fertility In: Textbook of Andrology: Edited by Wayne J. G. Hellstrom. Allen Press, Inc. Chapter 22, 1997.

INVITED CHAPTERS AND REVIEWS (cont’d)

Monga M and Hellstrom WJG: Cryptorchidism and Fertility In: Textbook of Andrology: Edited by Wayne J. G. Hellstrom. Allen Press, Inc., Chapter 36, 1997.

Monga M and Hellstrom WJG: Nongonococcal urethritis. In: Conn’s Current Therapy. Edited by Robert E. Rakel. W. B. Saunders Company, pgs. 736-37, 1997.

Hellstrom WJG; Monga M and Sofikitis N: Fertilidadee Infertilidade Humana: Oligospermia Idiop<tica. Edited by Claudio Tel`ken. MEDSI Editora MJdicare Cientifica Ltda. Chapter 41, pgs. 515-27 (1997).

Hellstrom WJG; Bivalacqua TJ, Champion HC and Kadowitz PJ: The Role of Nitric Oxide on Penile Blood Flow and Genitourinary Tract Function In: Nitric Oxide and the Regulation of the Peripheral Circulation. Edited by Philip J. Kadowitz and Dennis B. McNamara. Boston: Birkhauser, Biomedical Sciences, 1999.

Ruiz-Deya G and Hellstrom WJG: Management of Peyronie’s disease. In: Male Sexual Dysfunction: Basic Concepts, Diagnosis and Treatment. (In press)

Purohit S and Hellstrom WJG: Impotence. In: Conn’s Current Therapy 2000. (In press)

BOOKS:

Hellstrom WJG: Male Infertility and Sexual Dysfunction. In: Textbook of Andrology. Edited by Wayne J. G. Hellstrom. Springer-Verlag: New York, April, 1997.

Hellstrom WJG: Handbook of Sexual Dysfunction. Edited by Wayne J. G. Hellstrom. Allen Press: Lawrence, Kansas. January 1999.

AUDIO and VIDEO TAPES:

Hellstrom WJG: Innovations in Laparoscopic Varicocelectomy, April 1992.

Hellstrom WJG: Current controversies in Andrology. April 1995.

Hellstrom WJG: Transurethral alprostadil: A new option in the treatment of erectile dysfunction, Sept.1997.

Hellstrom WJG: New perspectives in the management of BPH. April 7, 1998.

Hellstrom WJG: New treatments in male sexual dysfunction. June 1, 1999